Design and synthesis of new bis-hydrazones and pyridine bis-hydrazones: application in the asymmetric Diels-Alder reaction
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چکیده
منابع مشابه
Convenient synthesis, anti-inflammatory, analgesic and ulcerogenic activites of some new bis-hydrazones and pyrazole derivatives.
The reaction of acid hydrazides (1a-c) with 2-chloro-1-(4-chlorophenyl)ethanone (2a) or 2-bromo-1-(4-bromophenyl)ethanone (2b) afforded bis-hydrazones 6a-d, while the reaction of la-c with 2-oxo-N-arylpropanehydrazonoyl chlorides (3a,b) furnished N-(aryl)propanehydrazonoyl chlorides 8a-c. The reaction of the latter chlorides with sodium benzenesulfinate furnished sulfones 11a-c. On the other ha...
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General Experimental Procedures: Melting points were determined using a metal block and are uncorrected. Optical rotations were measured at room temperature. H and C-NMR spectra were obtained in CDCl3 as the solvent with either TMS (0.00 ppm H, 0.00 ppm C) or CDCl3 (7.26 ppm, 77.00 ppm 13C) as an internal reference. FT-IR spectra were recorded for KBr pellets or films. EI-mass spectra were reco...
متن کاملSynthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents
In continuation of our endeavor towards the development of potent and effective antimicrobial agents, three series of halophenyl bis-hydrazones (14a-n, 16a-d, 17a and 17b) were synthesized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the identification of five molecules 14c, 14g, 16b, 17a and 17b (MIC range from 0.12 to 7.81 ...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولAsymmetric Catalysis of Diels–Alder Reaction
The Diels–Alder (DA) reaction (or diene synthesis) between a diene and a dienophile generates two s bonds stereoselectively and up to four chiral centers in a single step to afford six-membered cyclic compounds. This cycloaddition reaction named after Professor Otto Paul Hermann Diels (1876–1954) and his student Kurt Alder (1902–1958) was discovered in 1928 during studies on the reaction of b...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2012
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0014.205